Putin: “I leader del G7 a torso nudo sarebbero stati disgustosi, dovrebbero fare più sport”

Terremoto in Giappone, scossa di magnitudo 5.3 al largo delle isole OgasawaraStrage di Uvalde, la scuola della sparatoria in Texas sarà demolitaBisera Turkovic e il futuro dei Balcani: "La secessione è già iniziata"

Disneyland Paris: salmone affumicato contaminato, il parco lancia l'allarmeEmicrania per 1 bambino su 10,Guglielmo lascia 'impronte' su cervello e intestino di Adnkronos   22-07-2024 - 13:37 Link copiato #iubenda-cs-banner .iub_ts_bc:not(.iubenda-custom-content) *,#iubenda-cs-banner [class*=" iub"],#iubenda-cs-banner [class^=iub],.iubenda-tp-btn:not([data-tp-nostyle]){ 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(Adnkronos Salute) - L'emicrania non è una cosa da grandi. Colpisce anche i bambini, circa 1 su 10, tanto da lasciare le sue 'impronte' sul cervello: quello vero e proprio e il cosiddetto 'secondo cervello', cioè l'intestino. Lo dimostrano due studi dell'ospedale pediatrico Bambino Gesù di Roma, che hanno indagato la struttura cerebrale e la composizione del microbiota degli emicranici, scoprendo differenze significative tra il loro cervello o i loro batteri intestinali e quelli dei coetanei sani. Entrambe le ricerche aprono la strada a percorsi di cura mirati e personalizzati, spiegano dall'Irccs in occasione del World Brain Day in calendario oggi, 22 luglio. L'emicrania, la forma più frequente di cefalea primaria tra i bambini e gli adolescenti, è una patologia neurologica che colpisce circa l'11% della popolazione pediatrica - descrivono gli esperti del Bambino Gesù, il cui Centro per lo studio e la cura delle cefalee in età evolutiva segue ogni anno 1.500 nuovi casi di bambini emicranici, erogando circa 3.000 prestazioni tra visite ambulatoriali e day hospital - E' spesso dovuta a una predisposizione genetica, confermata dalla presenza di altri casi in famiglia. Può presentarsi a qualsiasi età, persino nei primi mesi di vita, anche se tra i più piccoli la malattia non si manifesta con il mal di testa, ma con sintomi come vomito ciclico, dolori addominali e articolari ricorrenti, vertigini, torcicollo e mal d'auto. Il primo studio, quello sul cervello, è stato condotto in 2 fasi da clinici e ricercatori delle unità di Neurologia dello sviluppo, Neuro-imaging funzionale e Fisica sanitaria del Bambino Gesù su 100 bambini e adolescenti affetti da emicrania e su un gruppo di controllo composto da 100 coetanei senza emicrania. Il lavoro, finanziato dal ministero della Salute e dall'International Headache Society, ha permesso di scoprire "alcune differenze significative tra emicranici e sani: attraverso la risonanza magnetica e la tecnica di analisi 'morphometric similarity' - si legge in una nota - sono state rilevate diverse modalità di connessione tra aree cerebrali, soprattutto quelle coinvolte nelle funzioni esecutive e nell'elaborazione degli stimoli del dolore, e in corrispondenza delle stesse aree anche una riduzione dello spessore della corteccia cerebrale. Inoltre, sono state osservate differenze nella connessione cerebrale tra maschi e femmine". "I risultati ci dicono che l'emicrania modifica la struttura del cervello in maniera progressiva fin dall'infanzia - commenta Massimiliano Valeriani, responsabile di Neurologia dello sviluppo del Bambino Gesù - L'evidenza delle impronte che la malattia lascia sulla struttura e sulla connessione fra aree cerebrali indica la necessità di intercettare, e quindi curare, i pazienti emicranici fin da piccoli. Inoltre, le differenze fra maschi e femmine emerse dalla nostra ricerca suggeriscono l'adozione di piani terapeutici che tengano conto anche del genere, prospettiva che non è mai stata presa in considerazione neanche per gli adulti". Il secondo studio, finanziato dal ministero della Salute, è stato condotto dalle unità di Neurologia dello sviluppo e di Microbiomica del Bambino Gesù su 98 pazienti emicranici tra 6 e 17 anni e su un gruppo di controllo composto da 98 coetanei. I ricercatori hanno confrontato campioni di feci, urine e sangue dei due gruppi. Attraverso l'analisi di specifici parametri, sono state individuate "differenze significative sia nelle componenti del microbiota intestinale che nelle loro funzioni". In particolare, riporta la nota, è emerso che "il profilo del microbiota degli emicranici influenza alcuni processi metabolici, come la produzione di serotonina e triptofano, implicati nell'insorgenza del mal di testa. Inoltre, le alterazioni riscontrate sembrano concorrere alla disbiosi intestinale (squilibro causato dall'eccedenza di batteri 'cattivi') e all'aumento della permeabilità dell'intestino, alimentando così le manifestazioni della malattia"."Le implicazioni terapeutiche del nostro studio sono significative - rimarca Laura Papetti, neuro-pediatra del Bambino Gesù coordinatrice della ricerca - Per i pazienti resistenti alle comuni terapie antiemicraniche potrebbero essere considerati il trapianto fecale e terapie dietetiche a base di probiotici e prebiotici. Ulteriori ricerche potranno chiarire la relazione tra le alterazioni dei processi metabolici dei bambini con emicrania e la risposta ai farmaci, aprendo la strada a cure sempre più mirate e personalizzate". di Adnkronos   22-07-2024 - 13:37 Link copiato Commenti Leggi la Netiquette

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