Istruttore equitazione nasconde al Fisco un milione, denunciato - Tiscali Notizie

Stewart Copeland a Milano con la sua opera orchestrale il 18 ottobreGiorgio Malan ha vinto la medaglia di bronzo nel pentathlon moderno alle Olimpiadi di Parigi - Il PostUcraina, bombe russe su un supermercato nella citta' di Kostyantynivka: morti e feriti - Tiscali Notizie

Fosso della Cecchignola, contro il prolungamento di via Kobler anche un'interrogazione parlamentareUniversità Texas,trading a breve termine immunologo Casali guida studio sui topi "umanizzati" di Italpress   15-07-2024 - 17:06 Link copiato #iubenda-cs-banner .iub_ts_bc:not(.iubenda-custom-content) *,#iubenda-cs-banner [class*=" iub"],#iubenda-cs-banner [class^=iub],.iubenda-tp-btn:not([data-tp-nostyle]){ -webkit-tap-highlight-color:transparent!important;clip:auto!important;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;-o-border-image:none!important;border-image:none!important;bottom:auto!important;clear:none!important;-webkit-column-count:auto!important;-moz-column-count:auto!important;-webkit-column-width:auto!important;-moz-column-width:auto!important;columns:auto!important;counter-increment:none!important;counter-reset:none!important;direction:inherit!important;float:none!important;font-family:-apple-system,sans-serif!important;font-style:inherit!important;font-variant:normal!important;left:auto!important;letter-spacing:normal!important;list-style:outside!important;max-height:none!important;max-width:none!important;min-height:0!important;opacity:1;outline:0!important;overflow:visible!important;overflow-x:visible!important;overflow-y:visible!important;position:static!important;quotes:"" ""!important;right:auto!important;table-layout:auto!important;text-align:left!important;text-decoration:none!important;text-indent:0!important;text-shadow:none!important;text-transform:none!important;top:auto!important;unicode-bidi:normal!important;white-space:normal!important;width:auto!important;word-break:normal!important;word-spacing:normal!important;z-index:auto!important;list-style-type:inherit!important;padding:0!important}#iubenda-cs-banner{ background:0 0!important;border:0!important;display:-webkit-box!important;display:-ms-flexbox!important;font-size:15px!important;height:100%!important;left:0!important;line-height:1.4!important;margin:0!important;opacity:0!important;overflow:hidden!important;padding:0!important;pointer-events:none!important;position:fixed!important;top:0!important;-webkit-transition:opacity .4s!important;-o-transition:opacity .4s!important;transition:opacity .4s!important;width:100%!important;will-change:opacity;z-index:99999998!important}#iubenda-cs-banner .iub_ts_bc:not(.iubenda-custom-content) *,#iubenda-cs-banner [class*=" iub"],#iubenda-cs-banner [class^=iub]{ -webkit-font-feature-settings:normal!important;font-feature-settings:normal!important;-webkit-appearance:none!important;-moz-appearance:none!important;appearance:none!important;background:0 0!important;border:none!important;border-radius:0!important;-webkit-box-shadow:none!important;box-shadow:none!important;-webkit-box-sizing:border-box!important;box-sizing:border-box!important;color:currentColor!important;-webkit-column-gap:normal!important;-moz-column-gap:normal!important;column-gap:normal!important;-webkit-column-rule:medium none #000!important;-moz-column-rule:medium none #000!important;column-rule:medium none #000!important;-webkit-column-span:none!important;-moz-column-span:none!important;column-span:none!important;font-size:100%!important;font-weight:inherit!important;height:auto!important;-webkit-hyphens:manual!important;-ms-hyphens:manual!important;hyphens:manual!important;line-height:inherit!important;margin:0!important;min-width:0!important;-webkit-perspective:none!important;perspective:none!important;-webkit-perspective-origin:50% 50%!important;perspective-origin:50% 50%!important;-webkit-transform:none!important;-ms-transform:none!important;transform:none!important;-webkit-transform-origin:50% 50%!important;-ms-transform-origin:50% 50%!important;transform-origin:50% 50%!important;-webkit-transform-style:flat!important;transform-style:flat!important;-webkit-transition:none!important;-o-transition:none!important;transition:none!important;vertical-align:baseline!important}#iubenda-cs-banner.iubenda-cs-overlay:before{ background-color:rgba(0,0,0,.5)!important;content:""!important;height:100%!important;left:0!important;pointer-events:auto!important;position:fixed!important;top:0!important;width:100%!important;z-index:1!important}#iubenda-cs-banner.iubenda-cs-center{ -webkit-box-align:center!important;-ms-flex-align:center!important;-webkit-box-pack:center!important;-ms-flex-pack:center!important;align-items:center!important;justify-content:center!important}#iubenda-cs-banner.iubenda-cs-top{ -webkit-box-align:start!important;-ms-flex-align:start!important;align-items:flex-start!important}#iubenda-cs-banner.iubenda-cs-bottom{ -webkit-box-align:end!important;-ms-flex-align:end!important;align-items:flex-end!important}#iubenda-cs-banner .iubenda-cs-brand>div,#iubenda-cs-banner.iubenda-cs-left{ -webkit-box-pack:start!important;-ms-flex-pack:start!important;justify-content:flex-start!important}#iubenda-cs-banner.iubenda-cs-right{ -webkit-box-pack:end!important;-ms-flex-pack:end!important;justify-content:flex-end!important}#iubenda-cs-banner .iub_ts_bc a:hover,#iubenda-cs-banner.iubenda-cs-visible{ opacity:1!important}#iubenda-cs-banner.iubenda-cs-visible>*{ pointer-events:auto!important}#iubenda-cs-banner.iubenda-cs-slidein .iubenda-cs-container{ -webkit-transition:-webkit-transform .4s!important;transition:transform .4s!important;-o-transition:transform .4s!important;transition:transform .4s,-webkit-transform .4s!important}#iubenda-cs-banner.iubenda-cs-slidein.iubenda-cs-top .iubenda-cs-container{ -webkit-transform:translateY(-48px)!important;-ms-transform:translateY(-48px)!important;transform:translateY(-48px)!important}#iubenda-cs-banner.iubenda-cs-slidein.iubenda-cs-bottom .iubenda-cs-container{ -webkit-transform:translateY(48px)!important;-ms-transform:translateY(48px)!important;transform:translateY(48px)!important}#iubenda-cs-banner.iubenda-cs-slidein.iubenda-cs-visible .iubenda-cs-container{ -webkit-transform:translateY(0)!important;-ms-transform:translateY(0)!important;transform:translateY(0)!important}#iubenda-cs-banner .iubenda-cs-container{ position:relative!important;z-index:2!important}#iubenda-cs-banner .iubenda-cs-brand{ -ms-flex-negative:0!important;flex-shrink:0!important;padding:16px!important}#iubenda-cs-banner .iubenda-cs-brand,#iubenda-cs-banner .iubenda-cs-brand>div,#iubenda-cs-banner .iubenda-cs-opt-group,#iubenda-cs-banner .iubenda-cs-opt-group>div{ display:-webkit-box!important;display:-ms-flexbox!important;display:flex!important}#iubenda-cs-banner .iubenda-cs-brand img{ max-height:56px!important;max-width:192px!important}#iubenda-cs-banner .iubenda-cs-content{ overflow:hidden!important;position:relative!important;-webkit-transition:-webkit-transform .4s!important;-o-transition:transform .4s!important;transition:transform .4s,-webkit-transform .4s!important;z-index:1!important}#iubenda-cs-banner .iub_ts_rtnl{ -webkit-box-orient:vertical!important;-webkit-box-direction:normal!important;display:-webkit-box!important;display:-ms-flexbox!important;display:flex!important;-ms-flex-direction:column!important;flex-direction:column!important;position:relative!important}#iubenda-cs-banner .iubenda-cs-close-btn{ cursor:pointer!important;font-size:24px!important;font-weight:lighter!important;height:48px!important;line-height:0!important;min-width:48px!important;padding:16px!important;position:absolute!important;right:0!important;text-align:center!important;top:-2px!important}#iubenda-cs-banner .iubenda-cs-close-btn:hover,#iubenda-cs-banner .iubenda-cs-opt-group button:hover{ opacity:.5!important}#iubenda-cs-banner .iub_ts_bc{ -webkit-box-flex:1!important;-ms-flex:1 1 auto!important;flex:1 1 auto!important;font-weight:300!important;margin:16px 16px 0!important;mask-image:linear-gradient(0deg,rgba(0,0,0,0) 0,#000 16px)!important;-webkit-mask-image:linear-gradient(0deg,rgba(0,0,0,0) 0,#000 16px)!important;overflow-y:auto!important;padding-bottom:32px!important}#iubenda-cs-banner .iub_ts_bc-padded{ padding-right:32px!important}#iubenda-cs-banner .iub_ts_bc a{ color:currentColor!important;cursor:pointer!important;opacity:.7!important;text-decoration:underline!important}#iubenda-cs-banner #iubenda-cs-title{ font-weight:700!important;margin-bottom:16px!important}#iubenda-cs-banner .iubenda-cs-opt-group{ -ms-flex-negative:0!important;flex-shrink:0!important;margin:0 16px 16px!important;z-index:1!important;color:#000!important}#iubenda-cs-banner .iubenda-cs-opt-group button{ -webkit-appearance:none!important;-moz-appearance:none!important;appearance:none!important;border-radius:64px!important;cursor:pointer!important;font-size:100%!important;font-weight:700!important;margin-bottom:4px!important;margin-top:4px!important;padding:8px 32px!important;text-align:center!important;background-color:hsla(0,0%,100%,.1)!important;color:#fff!important}#iubenda-cs-banner .iubenda-cs-opt-group button:focus{ opacity:.8!important}#iubenda-cs-banner.iubenda-cs-default .iubenda-cs-brand{ margin:0 -8px!important}@media (min-width:992px){ #iubenda-cs-banner.iubenda-cs-default .iubenda-cs-brand div{ margin:0 auto!important;width:960px!important}#iubenda-cs-banner.iubenda-cs-default .iub_ts_rtnl{ margin:16px auto!important;width:992px!important}}#iubenda-cs-banner.iubenda-cs-default .iubenda-cs-container,#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center:not(.iubenda-cs-top):not(.iubenda-cs-bottom) .iubenda-cs-opt-group>div,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-bottom):not(.iubenda-cs-center) .iubenda-cs-opt-group>div,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-top):not(.iubenda-cs-center) .iubenda-cs-opt-group>div{ width:100%!important}#iubenda-cs-banner.iubenda-cs-default-floating .iubenda-cs-brand{ margin:-8px -8px 0!important}#iubenda-cs-banner.iubenda-cs-default-floating .iubenda-cs-brand div{ margin:8px!important}@media (max-width:991px){ #iubenda-cs-banner.iubenda-cs-default .iubenda-cs-brand{ margin:-8px -8px 0!important}#iubenda-cs-banner.iubenda-cs-default .iubenda-cs-brand div{ margin:0 8px!important}#iubenda-cs-banner.iubenda-cs-default .iubenda-cs-content{ padding:8px!important}#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center.iubenda-cs-bottom .iubenda-cs-container,#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center.iubenda-cs-top .iubenda-cs-container{ width:100%!important}}@media (min-width:640px){ #iubenda-cs-banner .iubenda-cs-opt-group-custom{ -ms-flex-item-align:start!important;-webkit-box-pack:start!important;-ms-flex-pack:start!important;align-self:start!important;justify-content:flex-start!important;margin-right:auto!important}#iubenda-cs-banner .iubenda-cs-opt-group-consent{ -ms-flex-item-align:end!important;-webkit-box-pack:end!important;-ms-flex-pack:end!important;align-self:end!important;justify-content:flex-end!important;margin-left:auto!important}#iubenda-cs-banner .iubenda-cs-opt-group button:not(:last-of-type){ margin-right:8px!important}#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center:not(.iubenda-cs-top):not(.iubenda-cs-bottom) .iubenda-cs-container,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-bottom):not(.iubenda-cs-center) .iubenda-cs-container,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-top):not(.iubenda-cs-center) .iubenda-cs-container{ width:480px!important}}#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center:not(.iubenda-cs-top):not(.iubenda-cs-bottom) .iubenda-cs-opt-group,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-bottom):not(.iubenda-cs-center) .iubenda-cs-opt-group,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-top):not(.iubenda-cs-center) .iubenda-cs-opt-group{ -webkit-box-orient:vertical!important;-webkit-box-direction:normal!important;-ms-flex-direction:column!important;flex-direction:column!important}#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center:not(.iubenda-cs-top):not(.iubenda-cs-bottom) .iubenda-cs-opt-group button,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-bottom):not(.iubenda-cs-center) .iubenda-cs-opt-group button,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-top):not(.iubenda-cs-center) .iubenda-cs-opt-group button{ display:block!important;text-align:center!important;width:100%!important}#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center:not(.iubenda-cs-top):not(.iubenda-cs-bottom) .iubenda-cs-opt-group-custom,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-bottom):not(.iubenda-cs-center) .iubenda-cs-opt-group-custom,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-top):not(.iubenda-cs-center) .iubenda-cs-opt-group-custom{ -webkit-box-ordinal-group:3;-ms-flex-order:2;order:2}#iubenda-cs-banner.iubenda-cs-default-floating.iubenda-cs-center:not(.iubenda-cs-top):not(.iubenda-cs-bottom) .iubenda-cs-opt-group-consent,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-bottom):not(.iubenda-cs-center) .iubenda-cs-opt-group-consent,#iubenda-cs-banner.iubenda-cs-default-floating:not(.iubenda-cs-top):not(.iubenda-cs-center) .iubenda-cs-opt-group-consent{ -webkit-box-ordinal-group:2;-ms-flex-order:1;order:1}#iubenda-cs-banner.iubenda-cs-default-floating .iubenda-cs-content{ -webkit-box-shadow:0 8px 48px rgba(0,0,0,.15)!important;box-shadow:0 8px 48px rgba(0,0,0,.15)!important;padding:8px!important}#iubenda-cs-banner.iubenda-cs-fix-height .iub_ts_rtnl,#iubenda-cs-banner.iubenda-cs-fix-height .iubenda-cs-container,#iubenda-cs-banner.iubenda-cs-fix-height .iubenda-cs-content,.iubenda-mobile-sdk #iubenda-cs-banner .iub_ts_rtnl,.iubenda-mobile-sdk #iubenda-cs-banner .iubenda-cs-container .iubenda-cs-content,.iubenda-mobile-sdk #iubenda-cs-banner.iubenda-cs-visible .iubenda-cs-container{ height:100%!important}#iubenda-cs-banner.iubenda-cs-fix-height.iubenda-cs-default-floating .iubenda-cs-content{ height:calc(100% - 32px)!important}#iubenda-cs-banner.iubenda-cs-fix-height .iubenda-cs-brand img{ max-width:75%!important}#iubenda-cs-banner .iubenda-cs-opt-group button.iubenda-cs-btn-primary{ background-color:#0073ce!important;color:#fff!important}.iubenda-tp-btn:not([data-tp-nostyle]){ -webkit-font-feature-settings:normal!important;font-feature-settings:normal!important;-webkit-appearance:none!important;-moz-appearance:none!important;appearance:none!important;-webkit-backface-visibility:hidden!important;backface-visibility:hidden!important;background:#fff!important;border:none!important;border-radius:4px!important;-webkit-box-shadow:none!important;box-shadow:none!important;-webkit-box-shadow:0 0 0 1px rgba(0,0,0,.15)!important;box-shadow:0 0 0 1px rgba(0,0,0,.15)!important;-webkit-box-sizing:border-box!important;box-sizing:border-box!important;color:rgba(0,0,0,.65)!important;-webkit-column-gap:normal!important;-moz-column-gap:normal!important;column-gap:normal!important;-webkit-column-rule:medium none #000!important;-moz-column-rule:medium none #000!important;column-rule:medium none #000!important;-webkit-column-span:none!important;-moz-column-span:none!important;column-span:none!important;cursor:pointer!important;display:inline-block!important;font-size:14px!important;font-weight:700!important;height:34px!important;-webkit-hyphens:manual!important;-ms-hyphens:manual!important;hyphens:manual!important;line-height:34px!important;margin:0!important;min-width:34px!important;-webkit-perspective:none!important;perspective:none!important;-webkit-perspective-origin:50% 50%!important;perspective-origin:50% 50%!important;-webkit-transform:none!important;-ms-transform:none!important;transform:none!important;-webkit-transform-origin:50% 50%!important;-ms-transform-origin:50% 50%!important;transform-origin:50% 50%!important;-webkit-transform-style:flat!important;transform-style:flat!important;-webkit-transition:none!important;-o-transition:none!important;transition:none!important;vertical-align:middle!important;visibility:inherit!important}.iubenda-tp-btn[data-tp-icon]{ background-image:url("data:image/svg+xml;charset=utf-8,%3Csvg xmlns='http://www.w3.org/2000/svg' width='32' height='32'%3E%3Cpath fill='%231CC691' fill-rule='evenodd' d='M16 7a4 4 0 0 1 2.627 7.016L19.5 25h-7l.873-10.984A4 4 0 0 1 16 7z'/%3E%3C/svg%3E")!important;background-position:top .5px left 1px!important;background-repeat:no-repeat!important;background-size:32px 32px!important}.iubenda-tp-btn[data-tp-circle]{ border-radius:32px!important}.iubenda-tp-btn[data-tp-label]:after{ content:attr(data-tp-label)!important;padding:0 16px!important;white-space:nowrap!important}.iubenda-tp-btn[data-tp-label][data-tp-icon]:after{ padding-left:32px!important}.iubenda-tp-btn[data-tp-float]{ position:fixed!important;z-index:2147483647!important}.iubenda-tp-btn[data-tp-float]:not([data-tp-anchored]){ margin:16px!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]{ border-radius:6px!important;margin:0 16px!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover]):not([data-tp-label])[data-tp-float=center-left],.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover]):not([data-tp-label])[data-tp-float=center-right],.iubenda-tp-btn[data-tp-float][data-tp-anchored][data-tp-hover][data-tp-float=center-left],.iubenda-tp-btn[data-tp-float][data-tp-anchored][data-tp-hover][data-tp-float=center-right]{ margin:0!important;top:75%!important;-webkit-transform:translateY(-50%)!important;-ms-transform:translateY(-50%)!important;transform:translateY(-50%)!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover]):not([data-tp-label])[data-tp-float=center-left],.iubenda-tp-btn[data-tp-float][data-tp-anchored][data-tp-hover][data-tp-float=center-left]{ border-bottom-left-radius:0!important;border-left:0!important;border-top-left-radius:0!important;left:0!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover]):not([data-tp-label])[data-tp-float=center-right],.iubenda-tp-btn[data-tp-float][data-tp-anchored][data-tp-hover][data-tp-float=center-right]{ border-bottom-right-radius:0!important;border-right:0!important;border-top-right-radius:0!important;right:0!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover])[data-tp-label][data-tp-float=center-left],.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover])[data-tp-label][data-tp-float=center-right]{ border-bottom:0!important;border-bottom-left-radius:0!important;border-bottom-right-radius:0!important;margin:0!important;top:50%!important;-webkit-transform-origin:bottom!important;-ms-transform-origin:bottom!important;transform-origin:bottom!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover])[data-tp-label][data-tp-float=center-left]{ left:0!important;-webkit-transform:translateY(-50%) rotate(90deg)!important;-ms-transform:translateY(-50%) rotate(90deg)!important;transform:translateY(-50%) rotate(90deg)!important;-webkit-transform-origin:left bottom!important;-ms-transform-origin:left bottom!important;transform-origin:left bottom!important}.iubenda-tp-btn[data-tp-float][data-tp-anchored]:not([data-tp-hover])[data-tp-label][data-tp-float=center-right]{ right:0!important;-webkit-transform:translateY(-50%) rotate(-90deg)!important;-ms-transform:translateY(-50%) rotate(-90deg)!important;transform:translateY(-50%) rotate(-90deg)!important;-webkit-transform-origin:right bottom!important;-ms-transform-origin:right bottom!important;transform-origin:right bottom!important}.iubenda-tp-btn[data-tp-float][data-tp-float=bottom-left],.iubenda-tp-btn[data-tp-float][data-tp-float=bottom-right]{ bottom:0!important}.iubenda-tp-btn[data-tp-float][data-tp-float=bottom-left][data-tp-anchored],.iubenda-tp-btn[data-tp-float][data-tp-float=bottom-right][data-tp-anchored]{ border-bottom:0!important;border-bottom-left-radius:0!important;border-bottom-right-radius:0!important}.iubenda-tp-btn[data-tp-float][data-tp-float=top-left],.iubenda-tp-btn[data-tp-float][data-tp-float=top-right]{ top:0!important}.iubenda-tp-btn[data-tp-float][data-tp-float=top-left][data-tp-anchored],.iubenda-tp-btn[data-tp-float][data-tp-float=top-right][data-tp-anchored]{ border-top:0!important;border-top-left-radius:0!important;border-top-right-radius:0!important}.iubenda-tp-btn[data-tp-float][data-tp-float=bottom-left],.iubenda-tp-btn[data-tp-float][data-tp-float=top-left]{ left:0!important}.iubenda-tp-btn[data-tp-float][data-tp-float=bottom-right],.iubenda-tp-btn[data-tp-float][data-tp-float=top-right]{ right:0!important}.iubenda-tp-btn[data-tp-float][data-tp-hover][data-tp-label]:after{ display:block!important;max-width:0!important;opacity:0!important;overflow:hidden!important;padding:0!important;-webkit-transition:max-width .6s,padding .6s,opacity .6s!important;-o-transition:max-width .6s,padding .6s,opacity .6s!important;transition:max-width .6s,padding .6s,opacity .6s!important}.iubenda-tp-btn[data-tp-float][data-tp-hover][data-tp-label]:hover:after{ max-width:192px!important;opacity:1!important;padding-left:32px!important;padding-right:10px!important}.iubenda-mobile-sdk #iubenda-cs-banner.iubenda-cs-visible{ align-items:center!important;justify-content:center!important}.iubenda-mobile-sdk #iubenda-cs-banner .iubenda-cs-container{ display:flex!important;max-height:100%!important}.iubenda-mobile-sdk #iubenda-cs-banner .iubenda-cs-container .iubenda-cs-content{ border-radius:0!important;margin:0!important}.iubenda-mobile-sdk #iubenda-cs-banner .iubenda-cs-opt-group{ text-align:center!important}.iubenda-mobile-sdk #iubenda-cs-banner .iubenda-cs-close-btn,.iubenda-mobile-sdk #iubenda-iframe .iubenda-iframe-close-btn,.no-banner #iubenda-cs-banner{ display:none!important}.iubenda-mobile-sdk #iubenda-cs-banner .iub_ts_rtnl{ display:flex!important;flex-direction:column!important}.iubenda-mobile-sdk #iubenda-cs-banner .iub_ts_bc{ flex:1;margin:0!important;mask-image:linear-gradient(0deg,rgba(0,0,0,0) 0,#000 15%)!important;-webkit-mask-image:linear-gradient(0deg,rgba(0,0,0,0) 0,#000 15%)!important;max-height:inherit!important;overflow-y:auto!important;padding:16px 16px 48px!important}@media (min-width:992px){ #iubenda-cs-banner.iubenda-cs-default-floating .iubenda-cs-container{ width:992px!important}#iubenda-cs-banner.iubenda-cs-default-floating .iubenda-cs-content{ border-radius:4px!important;margin:16px!important}.iubenda-mobile-sdk #iubenda-cs-banner .iub_ts_bc,.iubenda-mobile-sdk #iubenda-cs-banner .iubenda-cs-opt-group{ margin:24px!important}.iubenda-mobile-sdk #iubenda-cs-banner.iubenda-cs-default .iub_ts_rtnl{ margin:0!important;width:100%!important}}.iubenda-mobile-sdk #iubenda-iframe .iub-popover-content,.iubenda-mobile-sdk #iubenda-iframe .iubenda-iframe-top-container{ position:relative!important}.iubenda-mobile-sdk #iubenda-iframe #iab-container{ bottom:0!important;left:0!important;position:absolute!important;right:0!important;top:0!important}.iubenda-mobile-sdk #iubenda-iframe #iubenda-iframe-popup{ height:100%!important;width:100%!important}.iubenda-mobile-sdk #iubenda-iframe{ background-color:transparent!important}.iubenda-mobile-sdk #iubenda-iframe iframe{ background-color:transparent!important;bottom:0!important;position:absolute!important;top:0!important}.iubenda-mobile-sdk #iubenda-iframe .iubenda-iframe-spinner{ top:50px!important}.iubenda-mobile-sdk #iubenda-iframe .iubenda-iframe-footer{ z-index:9999!important}.iubenda-mobile-sdk #iubenda-iframe.iub-popover-visible .iub-popover{ z-index:10000!important}.iubenda-mobile-sdk #iubenda-iframe .iub-popover-content>div,.iubenda-mobile-sdk #purposes-container{ -webkit-overflow-scrolling:touch!important;bottom:0!important;position:absolute!important;top:0!important}.iubenda-mobile-sdk #purposes-container{ left:0!important;overflow:auto!important;right:0!important}body:has(.iubenda-cs-banner){ height:100%!important;overflow:hidden!important}#iubenda-cs-banner .iubenda-cs-content{ background-color:#fff!important;color:#000!important;font-size:14px!important;height:100%!important}#iubenda-cs-banner .ts_iub_btn_grp{ color:#fff!important;justify-content:flex-start!important}#iubenda-cs-banner .iubenda-cs-opt-group button.ts_iub_btn_ok,#iubenda-cs-banner button.ts_iub_btn_cst{ background-color:#5f57a1!important;color:#fff!important}#iubenda-cs-banner .iubenda-cs-opt-group button.ts_iub_btn_rjct{ background-color:#5f57a1}#iubenda-cs-banner .iubenda-cs-opt-group button.ts_iub_btn_mr{ margin-left:0!important;margin-right:auto!important}#iubenda-cs-banner .iubenda-cs-container,#iubenda-cs-banner.iubenda-cs-default .iubenda-cs-container{ height:auto!important;max-height:100%!important}#iubenda-cs-banner .iub_ts_rtnl{ display:flex;flex-direction:column;height:100%}#iubenda-cs-banner .iub_ts_bc{ height:100%!important;max-height:45vh!important}@media only screen and (min-width:1024px){ #iubenda-cs-banner .iub_ts_bc{ max-height:none!important}}@media (max-width:639px){ #iubenda-cs-banner .iubenda-cs-opt-group{ -webkit-box-orient:vertical!important;-webkit-box-direction:normal!important;-ms-flex-direction:column!important;flex-direction:column!important;margin:12px!important}#iubenda-cs-banner .iubenda-cs-opt-group-custom{ -webkit-box-ordinal-group:3;-ms-flex-order:2;order:2}#iubenda-cs-banner .iubenda-cs-opt-group-consent{ -webkit-box-ordinal-group:2;-ms-flex-order:1;order:1}#iubenda-cs-banner .iubenda-cs-opt-group button{ display:block;margin:6px 3px!important;padding:8px 24px!important;text-align:center!important;width:100%!important}#iubenda-cs-banner .iubenda-cs-opt-group button.ts_iub_btn_rjct{ order:2!important}#iubenda-cs-banner .iubenda-cs-opt-group button.ts_iub_btn_pr{ order:3!important}#iubenda-cs-banner .iubenda-cs-opt-group button.ts_iub_btn_ok{ order:1!important}} #speakup-player{ margin: 0 !important; max-width: none !important; min-height: 85px !important; padding-bottom: 25px !important; padding-top: 10px !important;}#speakup-player:empty::after{ align-items: center; background-color: #fff; border-radius: 0.5rem; box-shadow: 0 12px 24px rgba(0, 0, 0, 0.12); font-family: sans-serif; content: 'Loading...'; display: flex !important; font-size: 13px; font-weight: bold; line-height: 1; justify-content: center; min-height: 50px; text-transform: uppercase;}#speakup-player:empty{ display: block;} ROMA (ITALPRESS) - Topi "umanizzati" con sistema immunitario umano. Passi avanti per la ricerca biomedica che promette nuove conoscenze nello sviluppo dell'immunoterapia e nel disease modeling. È quanto emerge dallo studio degli scienziati dell'Health Science Center dell'Università del Texas a San Antonio (Stati Uniti) che hanno creato, appunto, un modello di topo umanizzato con un sistema immunitario umano e un microbioma intestinale simile a quello umano in grado di produrre risposte anticorpali specifiche.A guidare il team di scienziati dell'Università americana un immunologo italiano: Paolo Casali, University of Texas Ashbel Smith Professor and Distinguished Research Professor, Department of Microbiology, Immunology and Molecular Genetics in the Joe R.and Teresa Lozano Long School of Medicine.Casali ha quasi cinquant'anni di esperienza nella ricerca biomedica in immunologia e microbiologia ed è tra i massimi ricercatori nel campo della genetica molecolare e dell'epigenetica della risposta anticorpale. Lo scopo del progetto, che apparirà nel numero di agosto di Nature Immunology, era superare i limiti dei modelli umani attualmente disponibili creando un topo umanizzato con un sistema immunitario umano completamente sviluppato e funzionale.I topi sono usati ampiamente nella ricerca biologica e biomedica perché sono piccoli, facili da maneggiare, condividono molti elementi immunitari e proprietà biologiche con gli esseri umani e sono facilmente modificabili geneticamente.Molti dei geni di risposta immunitaria dei topi, però, sono incongruenti con i corrispondenti umani.I primi topi umanizzati furono creati negli anni '80 per studiare l'infezione da HIV e la risposta immunitaria umana. Sono stati creati iniettando in topi immunodeficienti linfociti periferici umani, cellule staminali ematopoietiche o altre cellule umane.Tali modelli, tuttavia, non sviluppano un sistema immunitario umano pienamente funzionale, hanno una durata di vita breve e non generano risposte immunitarie efficienti. Ciò li rende inadatti allo sviluppo di immunoterapie umane in vivo, allo sviluppo di vaccini umani e all'human disease modeling.Il team di Casali ha iniziato iniettando intracardiacamente (ventricolo sinistro) cellule staminali umane. Dopo alcune settimane, i topi vengono condizionati ormonalmente con E2, la forma di estrogeno più potente e abbondante nel corpo. Tali topi umanizzati sono chiamati TruHuX o THX."Sfruttando in modo critico l'attività degli estrogeni per supportare la differenziazione delle cellule staminali umane e delle cellule immunitarie umane e le risposte anticorpali, i topi THX forniscono una piattaforma per gli studi sul sistema immunitario umano, lo sviluppo di vaccini umani e la sperimentazione di terapie", ha affermato Casali.-foto Agenzia Fotogramma -(ITALPRESS).col4/red15-Lug-24 17:06. di Italpress   15-07-2024 - 17:06 Link copiato Commenti Leggi la Netiquette

Università, il paradosso del governo sovranista che spinge i migliori a espatriareParigi 2024, Tamberi ci prova ma il sogno si infrange a 2.27: eliminato – Il Tempo

Grecia, il maltempo colpisce l'isola di Creta: un morto e diversi dispersi

Venezuela, la dissidente Mariela Magallanes: "Dávila rapito per zittire dissenso, Maduro permetta transizione"Salento, sub trovato morto a cinque chilometri dalla costa

La strage di Gioia Tauro, i legami sconci tra ‘Ndrangheta e estrema destraPerché la cerimonia di chiusura delle Olimpiadi è un problema per alcuni atleti - Focus.it

L'aumento netto di 100 euro in busta paga a settembre per 270mila lavoratori (con l'orario ridotto)"Principe Harry si annoia", ancora problemi con Meghan?