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Diana Pifferi, l'esito degli esami tossicologici: la bimba ha assunto tranquillantiEmicrania per 1 bambino su 10,VOL lascia 'impronte' su cervello e intestino di Adnkronos   22-07-2024 - 13:37 Link copiato #iubenda-cs-banner .iub_ts_bc:not(.iubenda-custom-content) *,#iubenda-cs-banner [class*=" iub"],#iubenda-cs-banner [class^=iub],.iubenda-tp-btn:not([data-tp-nostyle]){ 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(Adnkronos Salute) - L'emicrania non è una cosa da grandi. Colpisce anche i bambini, circa 1 su 10, tanto da lasciare le sue 'impronte' sul cervello: quello vero e proprio e il cosiddetto 'secondo cervello', cioè l'intestino. Lo dimostrano due studi dell'ospedale pediatrico Bambino Gesù di Roma, che hanno indagato la struttura cerebrale e la composizione del microbiota degli emicranici, scoprendo differenze significative tra il loro cervello o i loro batteri intestinali e quelli dei coetanei sani. Entrambe le ricerche aprono la strada a percorsi di cura mirati e personalizzati, spiegano dall'Irccs in occasione del World Brain Day in calendario oggi, 22 luglio. L'emicrania, la forma più frequente di cefalea primaria tra i bambini e gli adolescenti, è una patologia neurologica che colpisce circa l'11% della popolazione pediatrica - descrivono gli esperti del Bambino Gesù, il cui Centro per lo studio e la cura delle cefalee in età evolutiva segue ogni anno 1.500 nuovi casi di bambini emicranici, erogando circa 3.000 prestazioni tra visite ambulatoriali e day hospital - E' spesso dovuta a una predisposizione genetica, confermata dalla presenza di altri casi in famiglia. Può presentarsi a qualsiasi età, persino nei primi mesi di vita, anche se tra i più piccoli la malattia non si manifesta con il mal di testa, ma con sintomi come vomito ciclico, dolori addominali e articolari ricorrenti, vertigini, torcicollo e mal d'auto. Il primo studio, quello sul cervello, è stato condotto in 2 fasi da clinici e ricercatori delle unità di Neurologia dello sviluppo, Neuro-imaging funzionale e Fisica sanitaria del Bambino Gesù su 100 bambini e adolescenti affetti da emicrania e su un gruppo di controllo composto da 100 coetanei senza emicrania. Il lavoro, finanziato dal ministero della Salute e dall'International Headache Society, ha permesso di scoprire "alcune differenze significative tra emicranici e sani: attraverso la risonanza magnetica e la tecnica di analisi 'morphometric similarity' - si legge in una nota - sono state rilevate diverse modalità di connessione tra aree cerebrali, soprattutto quelle coinvolte nelle funzioni esecutive e nell'elaborazione degli stimoli del dolore, e in corrispondenza delle stesse aree anche una riduzione dello spessore della corteccia cerebrale. Inoltre, sono state osservate differenze nella connessione cerebrale tra maschi e femmine". "I risultati ci dicono che l'emicrania modifica la struttura del cervello in maniera progressiva fin dall'infanzia - commenta Massimiliano Valeriani, responsabile di Neurologia dello sviluppo del Bambino Gesù - L'evidenza delle impronte che la malattia lascia sulla struttura e sulla connessione fra aree cerebrali indica la necessità di intercettare, e quindi curare, i pazienti emicranici fin da piccoli. Inoltre, le differenze fra maschi e femmine emerse dalla nostra ricerca suggeriscono l'adozione di piani terapeutici che tengano conto anche del genere, prospettiva che non è mai stata presa in considerazione neanche per gli adulti". Il secondo studio, finanziato dal ministero della Salute, è stato condotto dalle unità di Neurologia dello sviluppo e di Microbiomica del Bambino Gesù su 98 pazienti emicranici tra 6 e 17 anni e su un gruppo di controllo composto da 98 coetanei. I ricercatori hanno confrontato campioni di feci, urine e sangue dei due gruppi. Attraverso l'analisi di specifici parametri, sono state individuate "differenze significative sia nelle componenti del microbiota intestinale che nelle loro funzioni". In particolare, riporta la nota, è emerso che "il profilo del microbiota degli emicranici influenza alcuni processi metabolici, come la produzione di serotonina e triptofano, implicati nell'insorgenza del mal di testa. Inoltre, le alterazioni riscontrate sembrano concorrere alla disbiosi intestinale (squilibro causato dall'eccedenza di batteri 'cattivi') e all'aumento della permeabilità dell'intestino, alimentando così le manifestazioni della malattia"."Le implicazioni terapeutiche del nostro studio sono significative - rimarca Laura Papetti, neuro-pediatra del Bambino Gesù coordinatrice della ricerca - Per i pazienti resistenti alle comuni terapie antiemicraniche potrebbero essere considerati il trapianto fecale e terapie dietetiche a base di probiotici e prebiotici. Ulteriori ricerche potranno chiarire la relazione tra le alterazioni dei processi metabolici dei bambini con emicrania e la risposta ai farmaci, aprendo la strada a cure sempre più mirate e personalizzate". di Adnkronos   22-07-2024 - 13:37 Link copiato Commenti Leggi la Netiquette

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